刘艳菊,1965年9月生,三级教授,博士生导师,第三届全国名老中医药专家学术继承人。国家中医药管理局中药炮制重点学科带头人、中药炮制技术传承基地负责人;中华中医药学会中药炮制分会副主任委员,国家自然基金网评专家,国家博士后基金评审专家,湖北省科技厅专家库成员。
主要研究方向为:中药饮片炮制工艺、质量标准及炮制机理研究。主持国家自然基金项目3项,科技部、国家中管局等项目20余项。获湖北省科技进步二等奖1项、三等奖2项,被相关部门收录中药饮片标准15项。主编专著2部,《中药炮制学》《中药炮制学专论》规划教材副主编, 参编教材及标准20余部,以第一或通讯作者发表论文90余篇,其中CSCD 及SCI 60余篇。
1.主持科研项目
(1) 国家自然基金(82074018),肠道菌群介导的苍术炒焦增强“固肠止泻”效应机制研究,55万,2021.1-2024.12
(2) 湖北省卫健委重点项目(ZY2021Z006),基于“性-效-物”相关性评价湖北英山苍术质量优势,10万,2021.1-2022.12
(3) 湖北省中央支持地方发展项目(2020YYD030),中药饮片药性评价与质量控制平台,100万,2021.1-2023.12
(4) 国家中管局(规财发字[2015]21),中药炮制技术传承基地,400,万,2015.7-2019.12
(5) 中央支持地方高校建设项目,中药饮片炮制工艺及质量控制平台,420万,2015.1-2017.12
(6) 科技部基础专项(2014FY111100-2),茅苍术等13味中药标准饮片制备技术规范研究,56.5万 2014.4-2019.3
(7) 国家中管局(201507002),莪术产地加工与炮制一体化关键技术研究,12万, 2015.7-2018.12
(8) 国家自然基金面上项目(81073051),麸炒苍术炮制机理研究,33万,2011.1-2013.12
(9) 湖北省自然基金重点项目(2011CDA024), 麸炒苍术燥湿健脾药效学研究,10万, 2011.1-2013.12
(8)国家中医药管理局(20100702-2),苍术饮片规格分级及其质量评价研究, 12万,2010.10-2014.4
2.获奖
(1)10味中药饮片炮制工艺及质量标准研究,湖北省科技进步奖,三等奖,2011年
(2)苍术、乌梅饮片炮制工艺及质量标准规范化研究,湖北省科技进步奖,三等奖,2007年
3.部分论文及专著
(1)Kun Shi, Linghang Qu , Xiong Lin , Ying Xie , Jiyuan Tu , Xianqiong Liu,Zhongshi Zhou , Guosheng Cao , Shuiqing Li and Yanju Liu *. Deep-Fried Atractylodis Rhizoma Protects against Spleen Deficiency-Induced Diarrhea through Regulating Intestinal Inflammatory Response and Gut Microbiota.[J]. International journal of molecular sciences,2020,21,124.
(2)Linghang Qu,Yiyi Xu,Guosheng Cao, Kang Xu,Jiyuan Tu , Xiong Lin,Guangzhong Wang , Shuiqing Li, Yanju Liu *. Effects of Atractylodes Oil on Inflammatory Responses and Serum Metabolites in Adjuvant Arthritis Rats.Biomedicine & pharmacotherapy. 2020 Apr,127 110130
(3)Jiyuan Tu, Ying Xie, Kang Xu, Linghang Qu, Xiong Lin, Chang Ke, Desen Yang, Guosheng Cao, Zhongshi Zhou,Yanju Liu*. Treatment of Spleen-Deficiency Syndrome With Atractyloside A From Bran-Processed Atractylodes lancea by Protection of the Intestinal Mucosal Barrier. Frontiers In Pharmacology., 20 November 2020| https://doi.org/10.3389/fphar.2020.583160 (IF:4.225)
(4)Ying Xie, Xin Zhan, Jiyuan Tu, Kang Xu,Xiongjie Sun, Chunlian Liu,Chang Ke Guosheng Cao ,Zhongshi Zhou*, Yanju Liu*. Atractylodes oil alleviates diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and intestinal barrier via SCF/c-kit and MLCK/MLC2 pathways. J Ethnopharmacol. 2021 Feb 13;272:113925
(5)Linghang Qu,Xiong Lin,Chunlian Liu,Chang Ke,Zhongshi Zhou,Kang Xu,Guosheng Cao* and Yanju Liu*.Atractylodin Attenuates Dextran Sulfate Sodium-induced Colitis byAlleviating Gut Microbiota Dysbiosis and Inhanbiting Inflammatory Response Through the MAPK Pathway. Frontiers In Pharmacology.,29April 2021, doi: 10.3389/fphar.2021.665376
(6)Ming Wu,Jing Xu,Xiong Lin,Xin Zhan,Kunyu Xiao,Lin Lei,Shuiqing Li*,Yanju Liu*.Enhanced release rate of the poorly water soluble ginsenoside Rg3 with ordered meso/macroporous silica. Journal of Porous Materials (2021) 28:711–716.
(7) Xianqiong Liu,Xinhua Song,Jie Zhang,Zhong Xu,Li Che,Yu Qiao,Yunuen Ortiz Pedraza,Antonio Cigliano,Rosa M. Pascale,Diego F. Calvisi,Yanju Liu* ,Xin Chen* . Focal adhesion kinase activatio limits efficacy of Dasatinibin c- Myc driven hepatocellular carcinoma. Cancer Medicine.2018,7(12):6170-6181.
(8) Qi Zhou, Zhongchuan Tan, Desen Yang, Jiyuan Tu, Yezi Wang ,Ying Zhang, Yanju Liu,* andGuoping Gan*. Improving the Solubility of Aripiprazole by Multicomponent Crystallization.Crystals.2021,11,343. https://doi.org/10.3390/cryst11040343
(9)瞿领航,曹国胜,涂济源,石坤,王洁,徐依依,刘艳菊*.基于灰色关联度与偏最小二乘法分析的苍术挥发油燥性谱效关系研究.中草药,2019,50(1):150-156. ISSN0253-2670.
(10)瞿领航,涂济源,曹国胜,赵佳文,潘许玲,刘艳菊*.基于燥胜则干和燥性伤阴理论的苍术燥性效应研究[J].中国中药杂志,2018,43(13):2705-2712.
(11)赵佳文,瞿领航,刘艳菊*,李水清,徐依依. 多成分含量测定结合UPLC 指纹图谱及其模式判别评价子芩与枯芩质量[J]. 中药材2017,40(9):2101-2106.
(12) 詹鑫,涂济源,刘春莲,柯畅,张方蕾,刘艳菊*.黄芩饮片临床习用规格的古今文献研究与思考.中国中药杂志.https://doi.org/10.19540/j.cnki.cjcmm.20210311.302
(13)《本草纲目·修治》新编,主编,湖北科技出版社,2021.4
(14)《中药炮制学》,副主编,中国中医药出版社,2016.8
(15) 《中药炮制学》,副主编,中国高等教育出版社,2016.8
(16)《中药炮制学专论》,副主编,人民卫生出版社,2017.9